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Related Concept Videos

Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Related Experiment Video

Updated: May 26, 2026

Assessing Whole-Body Lipid-Handling Capacity in Mice
07:57

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Published on: November 24, 2020

Pathophysiology of hypertriglyceridemia.

H C Hassing1, R P Surendran, H L Mooij

  • 1Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.

Biochimica Et Biophysica Acta
|December 20, 2011
PubMed
Summary
This summary is machine-generated.

Triglycerides (TG) are increasingly recognized as independent cardiovascular disease (CVD) risk factors, despite current guideline exclusions. Understanding TG pathophysiology reveals new therapeutic targets for hypertriglyceridemia.

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Last Updated: May 26, 2026

Assessing Whole-Body Lipid-Handling Capacity in Mice
07:57

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Published on: November 24, 2020

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro
09:41

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro

Published on: March 17, 2023

Area of Science:

  • Biochemistry
  • Cardiovascular Medicine
  • Metabolic Diseases

Background:

  • The role of triglycerides (TG) in cardiovascular disease (CVD) risk is debated.
  • International guidelines currently exclude TG from CVD risk calculators.
  • Recent evidence suggests plasma TG is an independent risk factor for CVD.

Purpose of the Study:

  • To review novel insights into triglyceride pathophysiology.
  • To explore potential new drug targets for hypertriglyceridemia.
  • To discuss future therapeutic strategies for triglyceride homeostasis.

Main Methods:

  • Review of current literature on triglyceride metabolism.
  • Discussion of mechanisms of hypertriglyceridemia: VLDL production, chylomicron synthesis, LPL-mediated lipolysis, and remnant clearance.
  • Focus on the roles of GPIHBP1, apolipoproteins, and heparin sulfate proteoglycans.

Main Results:

  • Hypertriglyceridemia arises from hepatic VLDL production, intestinal chylomicron synthesis, impaired LPL lipolysis, or defective remnant clearance.
  • GPIHBP1 and apolipoproteins are key players in lipolysis.
  • Heparin sulfate proteoglycans are crucial for hepatic remnant clearance.

Conclusions:

  • Understanding triglyceride pathophysiology is essential for developing novel therapies.
  • Targeting lipolysis and remnant clearance pathways offers promise for improving triglyceride homeostasis.
  • Further research is needed to integrate TG levels into CVD risk assessment and management.