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Related Experiment Video

Updated: May 26, 2026

Neural Activity Propagation in an Unfolded Hippocampal Preparation with a Penetrating Micro-electrode Array
09:48

Neural Activity Propagation in an Unfolded Hippocampal Preparation with a Penetrating Micro-electrode Array

Published on: March 27, 2015

A high aspect ratio microelectrode array for mapping neural activity in vitro.

Andrew B Kibler1, Brian G Jamieson, Dominique M Durand

  • 1Neural Engineering Center, Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.

Journal of Neuroscience Methods
|December 20, 2011
PubMed
Summary
This summary is machine-generated.

A new penetrating microelectrode array offers superior neural recording compared to traditional methods. This high-aspect-ratio device enables detailed two-dimensional mapping of brain activity, particularly in the hippocampus.

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Fabrication of Ti3C2 MXene Microelectrode Arrays for In Vivo Neural Recording
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Last Updated: May 26, 2026

Neural Activity Propagation in an Unfolded Hippocampal Preparation with a Penetrating Micro-electrode Array
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Published on: March 27, 2015

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Fabrication of Ti3C2 MXene Microelectrode Arrays for In Vivo Neural Recording
09:58

Fabrication of Ti3C2 MXene Microelectrode Arrays for In Vivo Neural Recording

Published on: February 12, 2020

Area of Science:

  • Neuroscience
  • Bioengineering
  • Materials Science

Background:

  • Traditional surface electrode arrays lack the penetration depth for high-fidelity neural recordings in critical brain regions like the hippocampus.
  • Penetrating electrodes are necessary for accurately capturing neural signals in complex tissue structures, such as the CA1-CA3 pyramidal cell layer.

Purpose of the Study:

  • To design and fabricate a novel high-aspect-ratio penetrating microelectrode array for enhanced neural activity recording.
  • To evaluate the performance of this array in two-dimensional recordings of neural activity in vitro.

Main Methods:

  • Fabrication of a 64-site silicon microelectrode array with high aspect ratio penetrating electrodes (200µm height, 20µm diameter) on a glass substrate.
  • Impedance measurement of individual electrodes (approx. 1.5MΩ).
  • Recording neural activity in a mouse unfolded hippocampus preparation using the array and comparing signal-to-noise ratio (S/N) with voltage-sensitive dye techniques.

Main Results:

  • The penetrating microelectrode array achieved a signal-to-noise ratio of 19.4±3dB, significantly higher than the 3.9±0.8dB S/N obtained with voltage-sensitive dye RH414.
  • Successfully recorded complex two-dimensional waves of neural activity in the unfolded hippocampus preparation.
  • Demonstrated superior data acquisition compared to voltage-sensitive dye techniques for broad-field, two-dimensional neuronal activity.

Conclusions:

  • The novel high-aspect-ratio penetrating microelectrode array provides superior performance for neural recording.
  • This array, especially when combined with the unfolded hippocampus preparation, is a powerful tool for imaging network activity across the entire hippocampus.
  • The technology offers a significant advancement for studying neural circuits and brain function.