Related Experiment Video
Updated: May 26, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
Inflammatory biomarkers in patients with asymptomatic primary hyperparathyroidism
Ahmed Alsayed Emam1, Sabela Gomaa Mousa, Karema Yousif Ahmed
1Department of Internal Medicine, National Research Center, Cairo, Egypt. ahmedemam6@hotmail.com
Objective:
To assess highly sensitive C-reactive protein (hs-CRP) and interleukin-6 (IL-6) as inflammatory biomarkers in patients with asymptomatic primary hyperparathyroidism (PHPT).
Materials And Methods:
A total of 26 patients with asymptomatic PHPT and 22 age- and sex-matched individuals as a control group were recruited for the study. Corrected serum calcium, phosphorus, alkaline phosphatase, serum 25-hydroxyvitamin D, intact parathyroid hormone (PTH), hs-CRP and IL-6 were measured for all subjects.
Results:
Serum hs-CRP and IL-6 were significantly higher in asymptomatic PHPT patients than in the control group (hs-CRP: 4.15 ± 0.54 vs. 2.24 ± 0.11 mg/l; IL-6: 4.50 ± 0.80 vs. 2.56± 0.29 pg/ml; p < 0.001). Moreover, in asymptomatic PHPT patients, serum PTH was significantly correlated with hs-CRP and IL-6 (r = 0.820, p < 0.001 and r = 0.787, p < 0.001, respectively).
Conclusion:
Inflammatory biomarkers were higher in patients with asymptomatic PHPT than in controls. Moreover, serum PTH was significantly correlated with inflammatory biomarkers which may suggest a subclinical inflammatory response in this group of patients.
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