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Increased FGFR1 copy number in lung squamous cell carcinomas
Hidefumi Sasaki1, Masayuki Shitara, Keisuke Yokota
1Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan. hisasaki@med.nagoya-cu.ac.jp
Molecular Medicine Reports
|December 20, 2011
Summary
Fibroblast growth factor receptor 1 (FGFR1) gene copy number increases are common in lung cancer, particularly in squamous cell carcinoma. This finding correlates with gender and smoking status in lung cancer patients.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Basic fibroblast growth factor (bFGF) and its receptor FGFR1 are implicated in host stromal response and angiogenesis.
- FGFR1 amplifications have been explored in lung cancer using large-scale SNP arrays.
Purpose of the Study:
- To investigate the correlation between FGFR1 gene copy number and clinicopathological features in non-small cell lung cancer (NSCLC).
Main Methods:
- Real-time PCR was used to analyze FGFR1 gene copy number in 100 surgically treated NSCLC cases.
- Clinicopathological data including gender, smoking status, and pathological subtype were collected.
Main Results:
- Increased FGFR1 gene copy number was observed in 32% of lung cancer patients.
- Higher FGFR1 copy number significantly correlated with male gender, smoking status, and squamous cell carcinoma subtype.
- No significant correlation was found between FGFR1 copy number and clinicopathological features within squamous cell carcinomas.
Conclusions:
- FGFR1 gene copy number alterations are frequent in NSCLC, especially in squamous cell carcinoma.
- FGFR1 copy number status is associated with specific demographic and lifestyle factors in lung cancer patients.
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