Related Experiment Video
Updated: May 26, 2026
14:57
Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
Meta-analysis demonstrates no association between p53 codon 72 polymorphism and prostate cancer risk
1Department of Urological Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.
Genetics and Molecular Research : GMR
|December 20, 2011
Summary
This meta-analysis found no link between the p53 codon 72 polymorphism and prostate cancer risk. The study included seven case-control studies, examining over 1900 individuals.
Area of Science:
- Genetics and Oncology
- Molecular Epidemiology
Background:
- The TP53 gene's codon 72 polymorphism (Pro/Arg) is investigated for its potential role in cancer development.
- Prostate cancer is a significant global health concern, and genetic factors may influence susceptibility.
Purpose of the Study:
- To determine if the p53 codon 72 polymorphism is associated with an increased risk of prostate cancer.
- To synthesize evidence from existing case-control studies through a meta-analysis.
Main Methods:
- A comprehensive literature search was conducted in PubMed, Embase, and CBM databases.
- Seven case-control studies comprising 892 prostate cancer cases and 1020 healthy controls were included in the meta-analysis.
- Statistical analyses were performed to assess the association under various genetic models and in different ethnic subgroups.
Main Results:
- Overall meta-analysis revealed no statistically significant association between p53 codon 72 polymorphism and prostate cancer risk across multiple comparison models.
- Subgroup analysis by ethnicity (Caucasian and Asian populations) also showed no significant association.
- Specific comparisons, including allele, homozygote, and heterozygote models, yielded non-significant odds ratios and confidence intervals.
Conclusions:
- The p53 codon 72 polymorphism does not appear to be a significant risk factor for prostate cancer.
- Further research may be warranted, but current evidence does not support a role for this specific polymorphism in prostate cancer susceptibility.
Related Concept Videos
02:23Abnormal Proliferation
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
01:19Interactions Between Signaling Pathways
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
01:05Single Nucleotide Polymorphisms-SNPs
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
02:36DNA Damage can Stall the Cell Cycle
In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
02:36DNA Damage Can Stall the Cell Cycle
In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...