Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ion Exchange01:17

Ion Exchange

Ion exchange chromatography separates charged molecules from a solution by reversibly exchanging them with mobile, or 'active', ions associated with the oppositely charged stationary phase. This method can be used to separate ions, soften and deionize water, and purify solutions. The polymers comprising the ion-exchange column are high-molecular-weight and chemically stable polymers, crosslinked to be porous and essentially insoluble. They are also functionalized with either acidic or basic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Survival outcomes in patients with sigmoid volvulus.

International journal of colorectal disease·2025
Same author

Small Interfering RNAs (siRNAs) Negatively Impact Growth and Gene Expression of Environmentally Relevant Bacteria in <i>In Vitro</i> Conditions.

Environmental science & technology·2024
Same author

The apparent metabolisable energy and ileal amino digestibility of black soldier fly (<i>Hermetia illucens</i>) larvae meal for broiler chickens.

British poultry science·2023
Same author

Re: 'Clinical impact of leakage in patients with handsewn vs stapled anastomosis after right hemicolectomy: a retrospective study'.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2020
Same author

Endomucosal resection of a rectal polyp at the dentate line, an alternative to transanal endoscopic microsurgery.

Techniques in coloproctology·2019
Same author

Synthetic hydrogels formed by thiol-ene crosslinking of vinyl sulfone-functional poly(methyl vinyl ether-alt-maleic acid) with α,ω-dithio-polyethyleneglycol.

Soft matter·2018

Related Experiment Video

Updated: May 26, 2026

Wet Chemistry and Peptide Immobilization on Polytetrafluoroethylene for Improved Cell-adhesion
06:15

Wet Chemistry and Peptide Immobilization on Polytetrafluoroethylene for Improved Cell-adhesion

Published on: August 15, 2016

Improving covalent cell encapsulation with temporarily reactive polyelectrolytes.

C M Gardner1, M A Potter, H D H Stöver

  • 1Department of Chemistry and Chemical Biology, McMaster University, Hamilton, ON, Canada. millscm@mcmaster.ca

Journal of Materials Science. Materials in Medicine
|December 20, 2011
PubMed
Summary
This summary is machine-generated.

Poly(methyl vinyl ether-alt-maleic anhydride) coated capsules showed reduced fibrotic overgrowth and enhanced strength, making them promising for cell encapsulation and transplantation. These findings suggest improved biocompatibility for biomedical applications.

More Related Videos

Reductive Electropolymerization of a Vinyl-containing Poly-pyridyl Complex on Glassy Carbon and Fluorine-doped Tin Oxide Electrodes
09:17

Reductive Electropolymerization of a Vinyl-containing Poly-pyridyl Complex on Glassy Carbon and Fluorine-doped Tin Oxide Electrodes

Published on: January 30, 2015

Cellular Encapsulation in 3D Hydrogels for Tissue Engineering
09:37

Cellular Encapsulation in 3D Hydrogels for Tissue Engineering

Published on: October 26, 2009

Related Experiment Videos

Last Updated: May 26, 2026

Wet Chemistry and Peptide Immobilization on Polytetrafluoroethylene for Improved Cell-adhesion
06:15

Wet Chemistry and Peptide Immobilization on Polytetrafluoroethylene for Improved Cell-adhesion

Published on: August 15, 2016

Reductive Electropolymerization of a Vinyl-containing Poly-pyridyl Complex on Glassy Carbon and Fluorine-doped Tin Oxide Electrodes
09:17

Reductive Electropolymerization of a Vinyl-containing Poly-pyridyl Complex on Glassy Carbon and Fluorine-doped Tin Oxide Electrodes

Published on: January 30, 2015

Cellular Encapsulation in 3D Hydrogels for Tissue Engineering
09:37

Cellular Encapsulation in 3D Hydrogels for Tissue Engineering

Published on: October 26, 2009

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Immunology

Background:

  • Developing biocompatible materials for cell encapsulation is crucial for transplantation therapies.
  • Assessing the host response to implanted biomaterials is essential for clinical success.
  • Covalently shell-crosslinked capsules offer potential advantages in stability and immune modulation.

Purpose of the Study:

  • To compare the biocompatibility and mechanical properties of different shell-crosslinked capsules.
  • To evaluate the host response, including fibrosis and inflammation, to encapsulated cell delivery systems.
  • To determine the optimal capsule coating for minimizing adverse reactions post-implantation.

Main Methods:

  • Calcium alginate/poly-L-lysine beads were coated with poly(methyl vinyl ether-alt-maleic anhydride) (PMM(50)) or poly(vinyl dimethyl azlactone-co-methacrylic acid) (PMV(50)).
  • Capsules, with and without C2C12 murine myoblast cells, were implanted in mice for up to 6 weeks.
  • Cell viability, capsule integrity, fibrotic overgrowth, mechanical strength, and inflammatory cytokine levels (TNF-α) were assessed.

Main Results:

  • PMM(50) coated capsules exhibited the least fibrotic overgrowth and highest mechanical strength.
  • PMM(50) capsules showed significantly lower TNF-α levels compared to controls at multiple time points.
  • Results for PMV(50) and sodium alginate coated capsules were variable, influenced by the presence of encapsulated cells.

Conclusions:

  • Poly(methyl vinyl ether-alt-maleic anhydride) (PMM(50)) coating provides superior biocompatibility and mechanical stability for encapsulated cell delivery systems.
  • PMM(50) coated capsules demonstrate reduced inflammatory response and fibrotic encapsulation, indicating potential for improved transplantation outcomes.
  • The choice of capsule coating material significantly impacts the host response and overall performance of cell encapsulation devices.