Related Experiment Video
Updated: May 26, 2026
Tear-Derived Exosomal miR-15a as New Diagnostic Tool for Diabetic Retinopathy
Published on: December 30, 2025
Diurnal variation of the tear osmolarity in normal subjects measured by a new microchip system
Banu Açikalin Oncel1, Eylem Pinarci, Yonca A Akova
1Ophthalmology Department, Baskent University Istanbul Hospital, Istanbul - Turkey. banuoncel@superonline.com
Purpose:
To show the diurnal variation of tear osmolarity in normal subjects.
Methods:
Thirty volunteers were recruited. Tear osmolarity was measured with TearLab osmolarity system at 3-hour regular intervals between 8:00 am and 5:00 pm. One-way analysis of variance test was used for statistical analysis.
Results:
Thirty healthy volunteers (all men) with a mean age of 29.6 ± 4.3 years (range 18-45) were recruited. The difference between measurements at 8:00 am and 11:00 am, 8:00 am and 2:00 pm, 8:00 am and 5:00 pm, 11:00 am and 2:00 pm, 11:00 am and 5:00 pm, and 2:00 pm and 5:00 pm were not statistically significant (one-way analysis of variance test, p>0.05).
Conclusions:
In normal subjects, tear osmolarity seems to have a stable profile during the daytime.
