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Update of randomized trials in recurrent disease
E Pujade-Lauraine1, J Alexandre
1Département d'Oncologie Médicale, Université Paris Descartes, Hôpital Hôtel-Dieu, Paris, France. epujade@arcagy.org
Summary
Advances in ovarian cancer management over the last decade focus on treating relapsed disease. Understanding the platinum-free interval (PFI) guides new targeted therapies and clinical trials for recurrent ovarian cancer.
Area of Science:
- Oncology
- Gynecologic Oncology
Background:
- Significant advances in first-line ovarian cancer therapy have been limited until recently.
- Progress in managing ovarian cancer relapse has driven observed improvements over the past decade.
Purpose of the Study:
- To review pivotal clinical trials that have significantly advanced recurrent ovarian cancer management in the last 10 years.
- To discuss the role of the platinum-free interval (PFI) in tailoring therapeutic strategies for ovarian cancer relapse.
- To highlight ongoing randomized phase II and III trials in recurrent ovarian cancer.
Main Methods:
- Review of pivotal clinical trials in recurrent ovarian cancer from the last decade.
- Analysis of therapeutic strategies based on platinum-free interval (PFI) length.
- Examination of ongoing randomized phase II and III trials in relapsed ovarian cancer.
Main Results:
- Knowledge of managing ovarian cancer relapse has led to most observed advances.
- The platinum-free interval (PFI) is a key criterion for predicting treatment success in recurrent ovarian cancer.
- Numerous targeted therapies are under investigation for recurrent ovarian cancer, with potential to alter disease course.
Conclusions:
- Future ovarian cancer treatment advances should prioritize randomized trials in recurrent disease.
- Distinct therapeutic strategies are now developed based on PFI length for ovarian cancer relapse.
- Ongoing and future clinical trials are crucial for advancing recurrent ovarian cancer treatment.
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