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Prevention of acetaminophen-induced hepatotoxicity by endotoxin in mice
M Ishikawa1, K Tanno, Y Takayanagi
1Department of Pharmacology and Toxicology, Tohoku College of Pharmacy, Sendai, Japan.
Research Communications in Chemical Pathology and Pharmacology
|July 1, 1990
Abstract:
A preliminary trial was conducted to determine if endotoxin would prevent acetaminophen (APAP)-induced hepatic toxicity. When mice were pretreated with endotoxin (1, 2 and 4 mg/kg, i.p.), the clinical chemistry profile and pathological alterations caused by APAP were reduced with a dose dependent manner. The efficacy of endotoxin in preventing APAP-induced hepatic necrosis should be further studied.
