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Non-contiguous finished genome sequence of the opportunistic oral pathogen Prevotella multisaccharivorax type strain
Abstract:
Prevotella multisaccharivorax Sakamoto et al. 2005 is a species of the large genus Prevotella, which belongs to the family Prevotellaceae. The species is of medical interest because its members are able to cause diseases in the human oral cavity such as periodontitis, root caries and others. Although 77 Prevotella genomes have already been sequenced or are targeted for sequencing, this is only the second completed genome sequence of a type strain of a species within the genus Prevotella to be published. The 3,388,644 bp long genome is assembled in three non-contiguous contigs, harbors 2,876 protein-coding and 75 RNA genes and is a part of the Genomic Encyclopedia of Bacteria and Archaea project.
Insights
This study presents the genome sequence of Prevotella multisaccharivorax, a bacterium linked to oral diseases like periodontitis. This research contributes valuable genomic data for understanding Prevotella species and their impact on human health.
Area of Science:
- Microbiology
- Genomics
- Oral Health Research
Background:
- Prevotella multisaccharivorax is a species within the Prevotella genus, known for its association with human oral diseases.
- The Prevotellaceae family includes several species implicated in conditions such as periodontitis and root caries.
- Despite the medical relevance of Prevotella, only a limited number of type strain genomes have been fully sequenced.
Purpose of the Study:
- To provide the first completed genome sequence of the type strain of Prevotella multisaccharivorax.
- To contribute to the Genomic Encyclopedia of Bacteria and Archaea project.
- To facilitate further research into the genetic makeup and pathogenic potential of Prevotella species.
Main Methods:
- Whole-genome sequencing of the Prevotella multisaccharivorax type strain.
- Bioinformatic analysis for genome assembly and gene identification.
- Comparative genomics within the Prevotella genus.
Main Results:
- The genome of Prevotella multisaccharivorax is 3,388,644 bp in length.
- The genome assembly consists of three non-contiguous contigs.
- It harbors 2,876 protein-coding genes and 75 RNA genes.
Conclusions:
- This genome sequence represents a significant resource for the study of Prevotella multisaccharivorax.
- It is the second completed genome sequence for a Prevotella type strain, enhancing genomic resources for the genus.
- Further investigation of this genome can elucidate the mechanisms behind oral disease development.
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