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Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Related Experiment Video

Updated: May 26, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

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Published on: February 6, 2020

Peptoids at the 7th Summit: toward macromolecular systems engineering.

K Eric Drexler

    Biopolymers
    |December 20, 2011
    PubMed
    Summary

    Peptoids, versatile peptide-like polymers, are emerging as key components in engineering complex self-assembled nanosystems. Their unique properties and parallels with proteins position them for advanced applications in foldamer science and nanotechnology.

    Area of Science:

    • Foldamer science and technology
    • Supramolecular assembly
    • Nanotechnology

    Background:

    • Peptoids offer facile synthesis of diverse peptide-like oligomers.
    • The 7th Peptoid Summit highlighted advancements and future prospects in peptoid science.
    • Rapid progress in DNA and protein engineering is enabling complex self-assembled nanosystems.

    Framework:

    • Comparative analysis reveals peptoids' suitability for self-assembled nanosystems.
    • Physical parallels between peptoids and proteins suggest the need for specialized design software.
    • Novel side-chain functionalities in peptoids can exploit unique binding interactions.

    Implementation:

    • Peptoid engineering requires specialized software, similar to protein engineering.
    • Crystal engineering principles can inform peptoid design for novel binding interactions.

    More Related Videos

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    13:42

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    Published on: November 2, 2011

    Synthesis and Mass Spectrometry Analysis of Oligo-peptoids
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    Published on: February 21, 2018

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    Last Updated: May 26, 2026

    Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
    09:34

    Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

    Published on: February 6, 2020

    Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets
    13:42

    Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets

    Published on: November 2, 2011

    Synthesis and Mass Spectrometry Analysis of Oligo-peptoids
    11:44

    Synthesis and Mass Spectrometry Analysis of Oligo-peptoids

    Published on: February 21, 2018

  • Integrating peptoid foldamer technology into existing nanotechnologies is crucial.

    • Implications:

    • Peptoids can contribute to the convergence of DNA, protein, and inorganic nanotechnologies.
    • This convergence facilitates the design and fabrication of atomically precise nanosystems.
    • Peptoid-based foldamer technologies expand the scope of macromolecular nanosystems engineering.