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Updated: May 26, 2026

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
Published on: July 28, 2010
Malignant tumours of colon and rectum from the blood clotting view
M Mytnik1, J Stasko, D Mistuna
1Clinic of Surgery, Faculty hospital JA Reimans, Presov, Slovakia. mytnik@fnsppresov.sk. mytnik@fnsppresov.sk
Objectives:
The relationship between malignant tumours and blood coagulation disorders is generally well known.
Background:
The authors notice blood coagulation in patients with colorectal cancer and evaluate prothrombotic markers.
Methods:
The authors analyzed a group of 137 patients with malignant tumour of colon and rectum, drew attention to the relationship between level of D-dimer, PAI-1, F 1+2, Protein C and the progress of malignant tumour, its localization, clinical stage, histopathology type, method of surgery considering the stapling use.
Results:
Very aggressive and advance tumours have high level of D dimer, plasminogen activator inhibitor I (PAI-1). Prothrombotic fragments 1+2 were significantly higher by anastomotic dehiscence. Protein C level was lower by age from sixty to seventy and in advanced clinical stage.
Conclusion:
Pre-operative surveys of D dimer, PAI-1, prothrombotic fragments and Protein C give informations abaout risk of thrombosis, far gone of malignant diseases, they clinical stage and histological type. D dimer and PAI-1 have the most clinical value (Fig. 5, Ref. 11).
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