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Updated: May 26, 2026
10:10
Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans
Published on: February 16, 2017
Mesenchymal stem cells in the aging and osteoporotic population
Francesca Veronesi1, Paola Torricelli, Veronica Borsari
1Preclinical and Surgical Studies Laboratory, Codivilla-Putti Research Institute--Rizzoli Orthopedica Institute, Bologna-Italy.
Critical Reviews in Eukaryotic Gene Expression
|December 21, 2011
Summary
Mesenchymal stem cells (MSCs) are vital for tissue repair but aging and osteoporosis alter their function. Understanding these changes is crucial for effective MSC-based therapies.
Area of Science:
- Regenerative Medicine
- Cell Biology
- Biomedical Engineering
Background:
- Mesenchymal stem cells (MSCs) possess self-renewal and differentiation capabilities, making them crucial for tissue repair and maintenance, particularly in the skeleton.
- MSCs are attractive for tissue engineering and regenerative medicine due to their osteogenic potential.
- Aging and bone diseases like osteoporosis significantly alter MSC behavior, affecting their self-renewal and differentiation.
- These alterations impact cell proliferation, differentiation pathways, cell cycle progression, and the production of critical cytokines and growth factors.
Purpose of the Study:
- To review and summarize existing literature on the intrinsic and extrinsic characteristics of human bone marrow and adipose tissue-derived MSCs.
- To analyze how aging and osteoporosis affect MSC behavior and therapeutic potential.
- To highlight the implications of these cellular modifications for the clinical application of MSCs.
Main Methods:
- Literature review of studies investigating human bone marrow and adipose tissue MSCs.
- Analysis of changes in MSCs related to aging and osteoporosis.
- Synthesis of data concerning MSC self-renewal, differentiation, proliferation, cell cycle, and cytokine production.
Main Results:
- Aging and osteoporosis induce significant changes in MSCs, affecting their self-renewal and differentiation potential.
- Reported modifications include alterations in cell proliferation, differentiation capacity, cell cycle phases, and cytokine/growth factor production.
- Some studies present contrasting results, indicating a complex interplay of factors influencing MSC behavior.
Conclusions:
- Cellular modifications in MSCs due to aging and osteoporosis are significant and must be carefully considered.
- These changes impact the efficacy of MSCs in therapeutic applications for skeletal repair and regeneration.
- Further research is needed to fully understand and potentially mitigate the effects of aging and disease on MSC function for clinical translation.
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