Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mycobacterium marinum MMAR_0267-regulated copper utilization facilitates bacterial escape from phagolysosome.

Communications biology·2024
Same author

Mycobacterium LacI-type Transcription Regulator Rv3575c Affects Host Innate Immunity by Regulating Bacterial <i>mce4</i> Operon-Mediated Cholesterol Transport.

ACS infectious diseases·2024
Same author

Laser-induced stripping defect for highly selective electrochemical quantification of dopamine: Anti-interference from other catecholamine neurotransmitters.

Talanta·2024
Same author

Role of Early On-Treatment Serum HBV RNA Declines in Predicting Hepatocellular Carcinoma Risk in Patients With Chronic Hepatitis B.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association·2024
Same author

Golden insights from a silver superatom.

National science review·2024
Same author

Mycobacterium smegmatis MfpC is a GEF that regulates mfpA translationally to alter the fluoroquinolone efficacy.

Communications biology·2024

Related Experiment Video

Updated: May 26, 2026

A Tuberculosis Molecular Bacterial Load Assay (TB-MBLA)
10:41

A Tuberculosis Molecular Bacterial Load Assay (TB-MBLA)

Published on: April 30, 2020

Progress on the biomarkers for tuberculosis diagnosis.

Tiwei Fu1, Jianping Xie

  • 1Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Beibei, Chongqing 400715, China.

Critical Reviews in Eukaryotic Gene Expression
|December 21, 2011
PubMed
Summary

New biomarkers from pathogen-host interactions show promise for monitoring active tuberculosis (TB). These include protein antigens and nucleic acids detectable in serum, sputum, urine, or breath, aiding infection identification and treatment assessment.

Related Experiment Videos

Last Updated: May 26, 2026

A Tuberculosis Molecular Bacterial Load Assay (TB-MBLA)
10:41

A Tuberculosis Molecular Bacterial Load Assay (TB-MBLA)

Published on: April 30, 2020

Area of Science:

  • Global health
  • Infectious diseases
  • Biomarker discovery

Background:

  • Tuberculosis (TB) is a significant global health challenge.
  • Monitoring active TB is crucial for effective treatment and control.
  • Pathogen-host interaction biomarkers offer a promising avenue for TB diagnostics.

Purpose of the Study:

  • To summarize recent advancements in biomarkers for active tuberculosis detection.
  • To review biomarkers derived from pathogen-host interactions.
  • To present the potential applications of these biomarkers in clinical settings.

Main Methods:

  • Literature review of recent progress in TB biomarker research.
  • Compilation of various types of potential biomarkers (e.g., protein antigens, cell-free nucleic acids, lipoarabinomannose).
  • Analysis of biomarker detectability in different biological samples (serum, sputum, urine, breath).

Main Results:

  • Identified diverse biomarkers originating from pathogen-host interactions.
  • Highlighted biomarkers measurable in easily accessible samples like serum, sputum, urine, and breath.
  • Compiled a range of specific biomarker candidates, including protein antigens, cell-free nucleic acids, and lipoarabinomannose.

Conclusions:

  • Biomarkers from pathogen-host interactions hold significant potential for active TB monitoring.
  • These biomarkers can aid in early infection identification and assessment of drug efficacy.
  • Further research and validation are needed to translate these findings into clinical practice.