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Updated: May 26, 2026
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Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers
Published on: September 19, 2017
Promoting the formation of tetramolecular G-quadruplexes under freezing condition
Qianqian Zhai1, Minggang Deng, Liang Xu
1College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, State Key Laboratory of Virology, Wuhan University, Hubei, Wuhan 430072, PR China.
Bioorganic & Medicinal Chemistry Letters
|December 21, 2011
Abstract:
In the study, we demonstrated that freezing was able to facilitate the short DNA strand T(4)G(4) to self-assemble into a tetramolecular G-quadruplex with a low DNA concentration in the absence of any ligand, providing a fast approach to configure intermolecular G-quadruplexes. The fast formation of intermolecular G-quadruplexes may offer a convenient tool.
