Related Experiment Video
Updated: May 26, 2026

Monitoring Dynamic Growth of Retinal Vessels in Oxygen-Induced Retinopathy Mouse Model
Published on: April 2, 2021
Is pertussis in infants a potential cause of retinal haemorrhages?
Ana Isabel Curcoy1, Victoria Trenchs, Marta Morales
1Emergency Department, Sant Joan de Deu Hospital, passeig Sant Joan de deu 2 08950, Barcelona, Spain. acurcoy@hsjdbcn.org
Insights
Retinal hemorrhages are not caused by pertussis (whooping cough) in infants. This study found no cases of retinal hemorrhages in infants hospitalized with pertussis, suggesting it
Area of Science:
- Pediatrics
- Ophthalmology
- Infectious Diseases
Background:
- Retinal hemorrhages in infants can be indicative of abusive head trauma.
- Differentiating abusive head trauma from other medical conditions is crucial.
Purpose of the Study:
- To determine the prevalence of retinal hemorrhages in infants diagnosed with pertussis.
- To aid in the differential diagnosis of abusive head trauma in infants.
Main Methods:
- Prospective study of 35 children aged 15 days to 2 years with pertussis.
- Ophthalmological examinations conducted within 72 hours of hospital admission.
- Further investigations to rule out systemic disorders or maltreatment if hemorrhages were detected.
Main Results:
- No retinal hemorrhages were observed in any of the 35 children with pertussis.
- The upper limit for the prevalence of retinal hemorrhages due to symptomatic pertussis requiring hospitalization was estimated at 9.9% (95% confidence).
Conclusions:
- Pertussis infection is unlikely to be a cause of retinal hemorrhages in children under two years of age.
- This finding helps in excluding pertussis as a cause when evaluating retinal hemorrhages in infants.
Aim:
To determine the prevalence of retinal haemorrhages in infants with pertussis infection with the purpose of clarifying the differential diagnosis of the cases of abusive head trauma.
Methods:
Prospective study of children aged 15 days to 2 years admitted to our hospital with a diagnosis of pertussis over a period of 4 years (May 2004-May 2008). All children underwent one detailed ophthalmological examination within 72 h of admission. If retinal haemorrhages were detected, further investigation was undertaken to rule out systemic disorder or maltreatment.
Results:
35 children with pertussis infection were examined. None was found to have retinal haemorrhages. Therefore, applying Wilson's method, the data suggest with 95% confidence that the true effect estimate for retinal haemorrhage occurring due to symptomatic pertussis infection requiring admission to hospital is no higher than 9.9%.
Conclusions:
Pertussis infections are unlikely to cause retinal haemorrhages in children under 2 years of age.
More Related Videos
Related Concept Videos
Diabetic Retinopathy
Bacterial Meningitis I: Introduction
Encephalitis l: Introduction
The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

