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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Association of home blood pressure variability with progression of chronic kidney disease

Tomonari Okada1, Hiroshi Matsumoto, Yume Nagaoka

  • 1Department of Nephrology, Tokyo Medical University, Tokyo, Japan. t-okada@tokyo-med.ac.jp

Blood Pressure Monitoring
|December 21, 2011
PubMed

Insights

Day-by-day home blood pressure (HBP) variability does not significantly predict chronic kidney disease (CKD) progression. This study found no association between HBP variability metrics and changes in kidney function or renal events in CKD patients.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Clinical Research

Background:

  • Home blood pressure (HBP) monitoring is recognized for predicting chronic kidney disease (CKD) progression.
  • Understanding the impact of blood pressure (BP) variability on CKD progression is crucial for clinical management.

Purpose of the Study:

  • To investigate the clinical significance of day-by-day HBP variability in predicting the progression of CKD.
  • To clarify the association between BP variability metrics and renal outcomes in patients with stage 3-5 CKD.

Main Methods:

  • Recruited 135 patients with stage 3-5 CKD for daily HBP measurements over 7 days.
  • Collected BP data morning and evening, with follow-up every 6 months for 36 months.
  • Analyzed associations between BP variability (SD, CV, ARV) and renal outcomes using multivariate regression and Cox proportional hazards analysis.

Main Results:

  • No significant correlations were observed between SD, CV, or ARV of morning systolic BP and the change in estimated glomerular filtration rate (eGFR).
  • Multivariate regression analysis showed no significant association between BP variability metrics and eGFR decline (P > 0.05).
  • Multivariate Cox analysis indicated that none of the BP variability metrics posed a significant risk for renal events (P > 0.05).

Conclusions:

  • Day-by-day BP variability, assessed through HBP measurements, demonstrated no significant association with CKD progression.
  • The findings suggest that short-term BP variability may not be a reliable predictor of renal outcomes in patients with moderate to advanced CKD.
Abstract

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