Related Experiment Video
Updated: May 26, 2026
Cochlear Implantation in the Guinea Pig
Published on: June 15, 2018
Cisplatin effects on guinea pigs: cochlear histology and genotoxicity
Cacineli Marion de Franceschi1, Tania Tochetto, Aron Ferreira da Silveira
1Curso de Fonoaudiologia Programa de Pós-Graduação em Distúrbios da Comunicação Humana, Universidade Federal de Santa Maria.
Unlabelled:
To understand how the DNA answers to external agents such as cisplatin may be relevant to the diagnosis and treatment of hearing disorders caused by the administration of such drug.
Objectives:
To investigate the cisplatin influence on the cochlea and DNA of guinea pigs.
Material And Methods:
Experimental study carried out with 12 guinea pigs (Cavia porcellus). The inclusion criterion was the presence of Preyer's reflex and distortion-product otoacoustic emissions. Guinea pigs were divided into two groups: Control Group (CG)--made up of six guinea pigs, to which we administrated saline solution during six consecutive days, intraperitoneally; and a Study Group (SG)--made up of six guinea pigs, to which we administrated cisplatin during six consecutive doses of 3mg/kg/day intraperitoneally. Twenty-four hours after the last administration of cisplatin the guinea pigs were slaughtered, blood samples were collected and the cochleae were removed.
Results:
The administration of cisplatin did not cause identifiable changes to the DNA. Histological analysis showed changes in the organ of Corti and spiral ganglion.
Conclusion:
Cisplatin causes changes in cochlear histology, such as the loss of the normal micro-cytoarchitecture of the organ of Corti, and reduction of neurons of the spiral ganglion with cell alterations, however, DNA damage was not detected.
