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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
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Published on: October 4, 2019

Terpenoids from endophytic fungi.

Jucimar Jorgeane de Souza1, Ivo José Curcino Vieira, Edson Rodrigues-Filho

  • 1Laboratory of Chemical Science, State University of North Fluminense Darcy Ribeiro 28013-602, Campos dos Goytacazes, RJ, Brazil.

Molecules (Basel, Switzerland)
|December 21, 2011
PubMed
Summary

Endophytic fungi produce diverse terpenoids, including sesquiterpenes and diterpenes. This review covers their production and biological activities from 2006-2010, identifying 127 unique compounds.

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Area of Science:

  • Mycology
  • Natural Product Chemistry
  • Biotechnology

Background:

  • Endophytic fungi reside within plant tissues, offering a rich source of novel bioactive compounds.
  • Terpenoids, a large class of natural products, exhibit a wide range of biological activities.
  • Research on fungal-derived terpenoids has expanded significantly in recent years.

Purpose of the Study:

  • To review the production of terpenoids by endophytic fungi.
  • To summarize the biological activities of these fungal-derived terpenoids.
  • To provide a comprehensive overview of research published between 2006 and 2010.

Main Methods:

  • Literature review of scientific publications from 2006 to 2010.
  • Identification and classification of terpenoids isolated from endophytic fungi.
  • Compilation of reported biological activities associated with these terpenoids.

Main Results:

  • A total of 127 terpenoids were isolated and characterized.
  • These included 65 sesquiterpenes, 45 diterpenes, five meroterpenes, and 12 other terpenes.
  • Various biological activities were associated with the identified terpenoids.

Conclusions:

  • Endophytic fungi are a prolific source of structurally diverse terpenoids.
  • The reviewed period (2006-2010) showed significant advancements in the discovery and characterization of these compounds.
  • Further investigation into the biological potential of fungal terpenoids is warranted.