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Primary localized amyloidosis presenting as diffuse amorphous calcified mass in both orbits: case report
Allan Christian Pieroni Gonçalves1, Rodrigo Bernal da Costa Moritz, Mário Luiz Ribeiro Monteiro
1Department of Ophthalmology, Universidade de São Paulo, Brazil.
Arquivos Brasileiros De Oftalmologia
|December 21, 2011
Summary
Primary localized amyloidosis, a rare orbital condition, can present with calcified masses. This case highlights that orbital calcification may indicate amyloidosis, not necessarily malignancy.
Area of Science:
- Ophthalmology
- Pathology
Background:
- Primary localized amyloidosis is an uncommon orbital disease.
- Orbital lesions with calcification are often suspected to be malignant.
Observation:
- A 63-year-old woman presented with bilateral proptosis and ophthalmoplegia.
- Imaging revealed infiltrative, calcified orbital masses.
- Biopsy confirmed amyloidosis through characteristic histological findings.
Findings:
- Microscopy showed extracellular amyloid deposits with Congo red staining and green birefringence.
- Systemic workup for amyloidosis was negative.
- The patient showed no disease progression over two years without treatment.
Implications:
- Orbital calcification in nonvascular lesions can be a sign of amyloidosis.
- This finding challenges the assumption that orbital calcification always indicates malignancy.
- Further investigation into rare causes of orbital masses is warranted.
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