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Relationship between body mass index of offspring and maternal smoking during pregnancy
1Faculty of Health Science, Gunma Paz College, Takasaki, Gunma, Japan. ino-t@sk9.so-net.ne.jp
Insights
Maternal smoking during pregnancy is linked to higher body mass index (BMI) and obesity index (OI) in 9- to 10-year-old children. These effects may persist regardless of other lifestyle factors.
Area of Science:
- Pediatric Health
- Environmental Health
- Public Health
Background:
- Maternal smoking during pregnancy is a known risk factor for adverse child health outcomes.
- Understanding the specific impact on offspring body composition is crucial for early intervention strategies.
Purpose of the Study:
- To investigate the association between maternal smoking during pregnancy and the body composition of elementary school children.
- To determine if this association is independent of other lifestyle and environmental factors.
Main Methods:
- A cohort of 1366 9- to 10-year-old children was studied.
- Data collected included parental questionnaires, passive smoking tests, urinary cotinine levels, and anthropometric measurements (BMI, OI).
- Urinary 8-hydroxydeoxyguanosine (8-OHdG) was measured to assess oxidative stress.
Main Results:
- Children of mothers who smoked during pregnancy exhibited significantly higher BMI and OI.
- Increased BMI and OI were correlated with the duration of maternal smoking.
- Maternal smoking's impact on BMI and OI remained significant even after accounting for confounding lifestyle factors.
Conclusions:
- Maternal smoking during pregnancy is a significant risk factor for elevated BMI and OI in offspring.
- The findings suggest that maternal smoking's influence on child body composition may be independent of common confounding factors.
- Early identification and intervention for children exposed to maternal smoking are warranted.
Objective:
To examine the relationship between maternal smoking during pregnancy and the body composition of offspring.
Subjects:
Grade 4 elementary school children (n=1366; boys/girls, 724/642; 9-10 years old) were enrolled in this study. All parents answered a lifestyle questionnaire, and children underwent passive smoking tests. Urinary cotinine measurement and lifestyle screening test parameters (that is, body weight, body length, body mass index (BMI), obesity index (OI), blood tests for liver function and lipid profile and questions regarding maternal smoking and lifestyle) were evaluated in terms of their relationship with maternal smoking. In addition, urinary 8-hydroxydeoxyguanosine (8-OHdG) concentration was measured in 80 randomly selected children to assess its relationship with oxidative stress.
Results:
Both BMI and OI were significantly higher in children whose mothers smoked during pregnancy than in those whose mothers never smoked (BMI: 17.2±2.7 vs 16.9±2.5 kg m(-2), P=0.016; OI: 2.7±14.3% vs 0.4±14.0%, P=0.003). The degree of elevation was positively correlated with the duration of maternal smoking. The increases in BMI and OI resulted from increased body weight and reduced height. The confounding factors-'breakfast with family', 'watching television at dinner', 'eating and drinking before sleep', 'watching television for >2 h', 'sleep duration <8 h' and 'playing sports'-were statistically significant. BMI and OI were significantly high in children whose mothers smoked during pregnancy in these six confounders. On the other hand, urinary 8-OHdG concentration was negatively correlated with BMI in children who had >1.3 ng ml(-1) urinary cotinine, suggesting that it may be related to basal metabolism due to oxidative stress.
Conclusion:
Maternal smoking is a risk factor for higher BMI and OI in 9- to 10-year-old children whose mothers smoke during pregnancy and may be independent of other confounding factors.
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