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Updated: May 26, 2026
11:02
Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
Precursor T-Cell acute lymphoblastic leukemia/lymphoma with rare presentation in the urinary bladder
Alexander Pham1, Amir Steinberg, Brian Kwok
1Department of Medicine and.
Hematology Reports
|December 21, 2011
Summary
This case study details a rare instance of Acute Lymphoblastic Leukemia (ALL) affecting the bladder. Successful treatment involved chemotherapy, radiation, and a stem cell transplant, leading to long-term remission.
Area of Science:
- Oncology
- Hematology
Background:
- Acute Lymphoblastic Leukemia (ALL) is a cancer of the blood and bone marrow.
- Bladder involvement in ALL is exceptionally rare, with limited documented cases.
Observation:
- A 22-year-old male diagnosed with T-cell ALL presented with a mediastinal mass.
- Initial treatment included hyperfractionated cyclophosphamide, vincristine, doxorubicin, dexamethasone (HyperCVAD) and mediastinal radiation.
- The patient experienced a relapse involving the bladder and bone marrow prior to maintenance therapy.
Findings:
- A nelarabine-based induction regimen successfully induced remission.
- Subsequent myeloablative allogeneic stem cell transplant (unrelated, 11/12 HLA-matched) was performed.
- The patient has maintained complete remission for over 409 days post-transplant.
Implications:
- This case highlights the possibility of bladder relapse in T-cell ALL.
- It underscores the potential efficacy of salvage chemotherapy and allogeneic stem cell transplantation in managing rare ALL presentations.
- Further research into mechanisms of sanctuary site relapse in ALL is warranted.
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