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Updated: May 26, 2026

Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases
Published on: January 1, 2016
Inhibition of lactophage activity by quinolinilporphyrin and its zinc compex
Natalia Vodzinska1, Boris Galkin, Yuriy Ishkov
1Biotechnological Scientific-Educational Centre of I.I Mechnikov Odessa National University, Odessa, Ukraine. nsvod@ukr.net
Abstract:
The influence of free base of quinolinilporphyrin and its Zn complex on infectivity of lactophages E3, E5 and E17 has been studied. The results of our investigations show that inhibition of lactophage activity by Zn complex of quinolinilporphyrin at concentration 10 microM and 20 microM was in the range 53-62% and 65-85%, respectively. The presence of this porphyrin in nutrient medium prevents the propagation of bacteriophage infection in Lactococcus lactis, but does not affect the phage adsorption process. The free base of quinolinilporphyrin slightly inhibits the activity of lactophages.
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