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Published on: September 26, 2018

[Hypogonadism and cardiovascular diseases in men]

    Terapevticheskii Arkhiv
    |December 22, 2011
    PubMed

    Insights

    Low sex hormone levels in men (male hypogonadism) increase cardiovascular disease risk, contrary to past beliefs. Testosterone therapy can improve metabolic syndrome components and reduce vascular complication risks.

    Area of Science:

    • Endocrinology
    • Cardiology
    • Metabolic Syndrome

    Context:

    • Historically, androgens were considered detrimental to the cardiovascular system.
    • Emerging evidence links male hypogonadism to increased cardiovascular disease (CVD) risk.
    • Metabolic syndrome components are implicated in this association.

    Purpose:

    • To analyze the correlation between male hypogonadism and cardiovascular diseases.
    • To elucidate the indirect mechanisms by which hypogonadism affects CVD risk.
    • To evaluate the potential benefits of testosterone replacement therapy (TRT) on cardiovascular risk factors.

    Summary:

    • Male hypogonadism, or low sex hormone levels, indirectly elevates cardiovascular disease risk through metabolic syndrome.
    • Testosterone therapy demonstrates potential to mitigate CVD risk factors.
    • Testosterone undecanoate (Nebido) offers sustained physiological testosterone levels for approximately 12 weeks post-injection, aiding in risk factor management.

    Impact:

    • Challenges the long-held view of androgens' adverse cardiovascular effects.
    • Highlights hypogonadism as a modifiable risk factor for cardiovascular diseases.
    • Supports testosterone therapy as a therapeutic strategy for improving cardiovascular health in hypogonadal men.

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