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Updated: May 26, 2026
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Quantification of Tumor Cell Adhesion in Lymph Node Cryosections
Published on: February 9, 2020
Relationship between lymph node metastases and histopathological parameters in carcinoma cervix: a multivariate
V R Pallavi1, K U Devi, G Mukherjee
1Department of Gynaecologic Oncology, Kidwai Memorial Institute of Oncology, Dr M. H. Marigowda Road, Bangalore, Karnataka, India.
Summary
Lymphovascular space involvement and full thickness stromal invasion are key indicators of lymph node metastasis in cervical cancer patients undergoing radical hysterectomy. These factors significantly predict the spread of disease, aiding in treatment planning.
Area of Science:
- Gynecologic Oncology
- Pathology
- Surgical Oncology
Background:
- Cervical cancer remains a significant global health concern.
- Radical hysterectomy with pelvic node dissection is a standard treatment for early-stage cervical cancer.
- Predicting lymph node metastasis is crucial for accurate staging and treatment selection.
Purpose of the Study:
- To identify clinicopathological factors associated with lymph node metastasis in patients with stage IB and IIA cervical carcinoma.
- To evaluate the predictive value of lymphovascular space involvement (LVSI) and stromal invasion for lymph node metastasis.
Main Methods:
- Retrospective review of 360 patients with stage IB/IIA cervical carcinoma treated with radical hysterectomy and pelvic node dissection (2000-2005).
- Analysis of histopathological features including tumor size, grade, LVSI, stromal invasion, parametrial, and vaginal margin involvement.
- Logistic regression analysis to determine significant predictors of lymph node metastasis.
Main Results:
- Lymph node metastasis was identified in 21.9% of patients.
- Lymphovascular space involvement (LVSI) and full-thickness stromal invasion were significantly associated with lymph node metastasis (p < 0.001 and p < 0.002, respectively).
- Tumor size, parametrial involvement, and vaginal margin status showed a trend but did not reach statistical significance in predicting lymph node metastasis.
Conclusions:
- Lymphovascular space involvement and full-thickness stromal invasion are independent predictors of lymph node metastasis in early-stage cervical cancer.
- These findings can assist in risk stratification and tailoring adjuvant therapy decisions.
- Accurate pathological assessment is vital for optimizing patient management in cervical cancer.
