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Gastroesophageal reflux disease accompanying urticaria pigmentosa

Magdalena Reich1, Adam Reich, Marta Rzeszutko

  • 1Department of Pediatrics, Gastroenterology and Nutrition, Wroclaw Medical University, Poland.

Acta Dermatovenerologica Croatica : ADC
|December 22, 2011
PubMed

Insights

This case study highlights a link between mastocytosis and gastroesophageal reflux disease (GERD) in a young child. Treatment targeting mastocytosis improved both skin and reflux symptoms, suggesting a common underlying cause.

Area of Science:

  • Pediatrics
  • Dermatology
  • Gastroenterology

Background:

  • Limited case reports suggest a potential association between mastocytosis and gastroesophageal reflux disease (GERD).
  • Urticaria pigmentosa, a form of cutaneous mastocytosis, can present with gastrointestinal manifestations.

Observation:

  • A 17-month-old boy with urticaria pigmentosa experienced worsening gastrointestinal symptoms, initially misdiagnosed as cow's milk allergy.
  • Clinical signs included skin lesions, pruritus, and a positive Darier's sign, leading to a diagnosis of cutaneous mastocytosis.

Findings:

  • 24-hour pH-metry confirmed increased acidic refluxes, and duodenal biopsy revealed numerous mast cells.
  • Gastrointestinal symptoms were attributed to mastocytosis, with significant improvement noted after treatment.

Implications:

  • This case underscores the importance of considering mastocytosis in pediatric patients with refractory GERD and skin manifestations.
  • Effective management of mastocytosis may alleviate associated gastrointestinal symptoms, improving quality of life.

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