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Clinical characteristics of obstructive uropathy associated with rotavirus gastroenteritis in Japan

Akira Ashida1, Mikiya Fujieda, Kazuhide Ohta

  • 1Department of Pediatrics, Osaka Medical College, Osaka, Japan. ped006@poh.osaka-med.ac.jp

Clinical Nephrology
|December 22, 2011
PubMed

Insights

Acute obstructive uropathy is a rare complication of rotavirus gastroenteritis in children. This study identified key clinical features and emphasizes the need for prompt diagnosis and management in affected pediatric patients.

Area of Science:

  • Pediatric Nephrology
  • Pediatric Gastroenterology
  • Infectious Diseases

Background:

  • Rotavirus gastroenteritis commonly causes dehydration and pre-renal azotemia.
  • Acute obstructive uropathy is an uncommon but serious complication observed in children with rotavirus gastroenteritis.

Purpose of the Study:

  • To investigate the epidemiology and clinical characteristics of acute obstructive uropathy associated with rotavirus gastroenteritis in Japanese children.
  • To raise awareness of this rare condition among healthcare professionals.

Main Methods:

  • A nationwide survey was conducted using questionnaires distributed to pediatric nephrologists and researchers who published on this topic in Japan.
  • Data collected included patient demographics, stone composition, laboratory findings, and clinical course.

Main Results:

  • Twenty-one cases were analyzed, with patients aged 0.4 to 3 years, predominantly male.
  • Oliguria typically appeared around 7 days post-gastroenteritis onset, often accompanied by hyperuricemia and hyponatremia.
  • Ammonium acid urate stones were the primary finding; patients recovered renal function upon discharge.

Conclusions:

  • Acute obstructive uropathy secondary to rotavirus gastroenteritis, though rare, requires consideration in pediatric cases of refractory anuria or persistent oliguria after gastrointestinal symptom resolution.
  • Early recognition and intervention are crucial for favorable outcomes.
Abstract

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