Related Experiment Video
Updated: May 26, 2026

08:38
Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
Published on: November 8, 2015
Tacrolimus-induced thrombotic microangiopathy: natural history of a severe, acute vasculopathy
John M Carson1, Eric D Newman, John L Farber
1Department of Medicine, Thomas Jefferson University Hospital, Philadelphia, PA , USA.
Clinical Nephrology
|December 22, 2011
Abstract:
Calcineurin inhibitors (CNI) have been clearly associated with posttransplant thrombotic microangiopathy (PTTMA). We report a case of de novo PT-TMA involving predominantly small arteries and arterioles of a renal allograft in a patient receiving tacrolimus. Serial biopsies demonstrate the natural history of this lesion through the chronic nonspecific phase. The case is discussed in the context of a literature review of PT-TMA in general and CNI use in particular.
