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Updated: May 26, 2026

Identifying Bone Marrow Microenvironmental Populations in Myelodysplastic Syndrome and Acute Myeloid Leukemia
Published on: November 10, 2023
Acute myeloid leukemia with myelodysplasia-related changes mimicking acute promyelocytic leukemia
Hisanori Machida1, Tsutomu Shinohara, Yoshihito Iwahara
1Division of Pulmonary Medicine, National Hospital Organization National Kochi Hospital, Japan. machidah@Kochi2.hosp.go.jp
Abstract:
We describe a patient with acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) that clinically resembled acute promyelocytic leukemia (APL). The karyotype of his leukemic cells was 46, XY, del (3) (q?) and did not include a chromosomal translocation involving the retinoic acid receptor-α gene. However, retinoic acid syndrome developed, and partial remission was achieved after treatment with all-trans retinoic acid (ATRA) followed by chemotherapy. Our case might provide new insights into the mechanism of the growth inhibitory effect of ATRA on APL-like cells.
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