Related Experiment Video
Updated: May 26, 2026
07:40
Whole-Mount Staining, Visualization, and Analysis of Fungiform, Circumvallate, and Palate Taste Buds
Published on: February 11, 2021
Bmp signalling in filiform tongue papillae development.
Katsushige Kawasaki1, Thantrira Porntaveetus, Shelly Oommen
1Department of Craniofacial Development, GKT Dental Institute, King's College, Guy's Hospital, London Bridge, London SE1 9RT, UK.
Archives of Oral Biology
|December 22, 2011
Summary
Bone morphogenetic protein (Bmp) signaling regulates filiform papillae shape. This study investigated Bmp signaling
Area of Science:
- Developmental biology
- Oral biology
- Molecular genetics
Background:
- Tongue papillae, including filiform papillae, are crucial for mastication and mechanical functions.
- Filiform papillae exhibit distinct morphologies (pointed vs. rounded tips) based on tongue location.
- The developmental mechanisms determining filiform papillae shape remain largely unknown.
Purpose of the Study:
- To investigate the role of Bone morphogenetic protein (Bmp) signaling in the development and shaping of filiform papillae.
- To elucidate how Bmp signaling influences the distinct morphologies of filiform papillae.
Main Methods:
- Comparative in situ hybridization was used to analyze the expression of Bmp and Bmpr genes during filiform papillae development.
- Mice over-expressing Noggin under the keratin14 promoter (K14-Noggin) were examined to assess the impact on papillae morphology.
Main Results:
- A dynamic temporo-spatial expression pattern of Bmps was identified during filiform papillae development.
- K14-Noggin mice displayed pointed filiform papillae in areas typically characterized by rounded papillae.
Conclusions:
- Bmp signaling is a key regulator of filiform papillae shape determination.
- Understanding Bmp signaling pathways provides insights into the development of oral structures.
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