Anti-inflammatory activity of ethanol extract of Vitex glabrata leaves

Vitex glabrata (Verbenaceae) is commonly employed for the treatment of various ailments in traditional medicine. In this study, ethanol extract of Vitex glabrata (EEVG) was evaluated for the anti-inflammatory activity using carrageenan-induced paw edema and cotton pellet induced granuloma formation in rat models. EEVG showed significant anti-inflammatory activity in rats in dose dependant manner. At a dose of 400 mg/kg, p.o. maximum effect was observed and was comparable (p<0.05) to that of diclofenac sodium (standard, 50 mg/kg, p.o.). Results of the study suggested that the anti-inflammatory activity of EEVG may be due to inhibition of prostaglandins synthesis and cessation of inflammatory events like fibroblast cell formation, neutrophils infiltration, and accumulation of fluids. Therefore, this study provides a support for the plant in the management of inflammatory related disorders.