Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Positive Regulator Molecules02:39

Positive Regulator Molecules

Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
Positive Regulator Molecules01:45

Positive Regulator Molecules

To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
The Cell Cycle Control System01:28

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Base Editing of <i>HBG1</i> and <i>HBG2</i> Promoters for Sickle Cell Disease.

The New England journal of medicine·2026
Same author

A control theoretical approach to gene regulation reveals quantitative constraints for dynamic homeostasis in stochastic gene expression.

Biochimica et biophysica acta. Molecular basis of disease·2026
Same author

Protein Kinase A Phosphorylates a Conformationally High-energy State of Raf Kinase Inhibitory Protein.

Journal of molecular biology·2025
Same author

BCMA-targeting BiTE molecule AMG 420 in relapsed or refractory multiple myeloma: a phase 1b open-label expansion study.

Leukemia & lymphoma·2025
Same author

Direct inhibition of tumor hypoxia response with synthetic transcriptional repressors.

Nature chemical biology·2024
Same author

Nonmonotone invasion landscape by noise-aware control of metastasis activator levels.

Nature chemical biology·2023

Related Experiment Video

Updated: May 26, 2026

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
12:26

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay

Published on: May 3, 2018

An integrated view of cyclin E function and regulation.

Ka Tat Siu1, Marsha Rich Rosner, Alex C Minella

  • 1Department of Medicine, Hematology/Oncology Division, Integrated Graduate Program in the Life Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Cell Cycle (Georgetown, Tex.)
|December 22, 2011
PubMed
Summary
This summary is machine-generated.

High cyclin E levels in cancer are linked to tumor aggression. This review explores how FBXW7 mutations and other factors deregulate cyclin E, impacting cell functions like proliferation and survival.

More Related Videos

Studying Proteolysis of Cyclin B at the Single Cell Level in Whole Cell Populations
10:54

Studying Proteolysis of Cyclin B at the Single Cell Level in Whole Cell Populations

Published on: September 17, 2012

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
12:02

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

Related Experiment Videos

Last Updated: May 26, 2026

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
12:26

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay

Published on: May 3, 2018

Studying Proteolysis of Cyclin B at the Single Cell Level in Whole Cell Populations
10:54

Studying Proteolysis of Cyclin B at the Single Cell Level in Whole Cell Populations

Published on: September 17, 2012

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
12:02

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • Cancers often exhibit high cyclin E levels, correlating with increased tumor aggression.
  • Loss-of-function mutations in FBXW7 are one mechanism disabling normal cyclin E control in cancer.
  • FBXW7 encodes a tumor suppressor protein crucial for targeting oncoproteins for degradation.

Purpose of the Study:

  • To review the function of mammalian cyclin E in light of recent data.
  • To discuss the complex network regulating cyclin E expression and activity.
  • To explore the consequences of deregulated cyclin E in cancer cells.

Main Methods:

  • Literature review of recent reports on cyclin E function and regulation.
  • Analysis of the connection between cyclin E and cellular control mechanisms.
  • Discussion of FBXW7's role in cyclin E regulation and cancer.

Main Results:

  • Inappropriate cyclin E expression has broad biological consequences.
  • Altered gene expression programs governing proliferation, differentiation, survival, and senescence are linked to cyclin E.
  • Multiple mechanisms beyond FBXW7 mutations can deregulate cyclin E in cancer.

Conclusions:

  • Cyclin E plays a critical role in cell physiology beyond its canonical cell cycle functions.
  • Understanding the network connecting cyclin E to its regulators is key for cancer research.
  • Further investigation into cyclin E deregulation offers potential therapeutic avenues.