Related Experiment Video

Updated: May 26, 2026

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

Clinical predictors of cognitive decline in patients with mild cognitive impairment: the Chongqing aging study

Ling Li1, Yanjiang Wang, Jiachuan Yan

  • 1Department of Neurology, Third Military Medical University, Daping, Chongqing, China.

Journal of Neurology
|December 22, 2011
PubMed

Insights

Identifying early predictors of dementia is crucial. Vascular risk factors, carotid stenosis, and white matter changes significantly impact cognitive decline in mild cognitive impairment (MCI) patients, suggesting potential interventions.

Area of Science:

  • Neurology
  • Gerontology
  • Radiology

Background:

  • Mild cognitive impairment (MCI) represents an early stage of dementia with no current effective treatments.
  • Early intervention in MCI is key to preventing progression to dementia.
  • Vascular risk factors (VRFs), carotid stenosis, and white matter changes (WMC) are hypothesized predictors of MCI prognosis.

Purpose of the Study:

  • To comprehensively screen for clinical predictors of MCI prognosis.
  • To investigate the independent predictive roles of VRFs, carotid stenosis, and WMC in MCI progression.
  • To identify factors associated with cognitive decline and conversion to dementia in MCI patients.

Main Methods:

  • 257 MCI patients underwent baseline assessments: VRF data, neuropsychological tests, computed tomography angiography (CTA) for carotid stenosis, and magnetic resonance imaging (MRI) for WMC severity.
  • A 3-year follow-up included repeat assessments of cognitive function, carotid stenosis, and WMC.
  • Statistical analysis identified predictors of cognitive decline and MCI conversion.

Main Results:

  • The annual conversion rate from MCI to dementia was 11.65%, and to Alzheimer's disease was 7.05%.
  • Cognitive decline correlated with diabetes mellitus, baseline WMC severity, baseline carotid stenosis, and WMC severity change.
  • Diabetes, baseline WMC severity, moderate-to-severe baseline carotid stenosis, and changes in carotid stenosis predicted conversion to dementia.

Conclusions:

  • Controlling blood glucose levels is important for managing MCI.
  • Addressing carotid stenosis and improving cerebral perfusion may delay cognitive decline in MCI.
  • Identifying and managing VRFs, WMC, and carotid stenosis are crucial for preventing dementia conversion from MCI.

More Related Videos

Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients07:42

Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients

Published on: December 16, 2022

Digital Handwriting Analysis of Characters in Chinese Patients with Mild Cognitive Impairment05:58

Digital Handwriting Analysis of Characters in Chinese Patients with Mild Cognitive Impairment

Published on: March 11, 2021

Related Concept Videos

Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Dementia01:30

Dementia

Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual.
Dementia l: Introduction01:22

Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists01:30

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function. They...