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Updated: May 26, 2026
Ex Vivo Corneal Organ Culture Model for Wound Healing Studies
Published on: February 15, 2019
Clinical study on interferon treatment of early scarring in filtering bleb
Wenhua Wang1, Jianli Zhang, Yan Huang
1Department of Ophthalmology, People's Hospital of Lianjiang, Lianjiang, Guangdong Province, China. wangwenhua741204@163.com
Purpose:
To investigate the effectiveness of needle revision combined with subconjuctival injection of interferon α-2b in reversing early scarring of filtering blebs following trabeculectomy surgery.
Methods:
Twenty-five glaucoma patients (31 eyes) who presented with scarred or encapsulated filtering bleb after glaucoma surgery underwent needle revision in combination with subconjuctival injection of interferon α-2b, and were followed for 12 months. Intraocular pressure (IOP) and filtering bleb morphology were observed post treatment.
Results:
The mean time until scarring occurred was 21.0±7.4 days. The average time between recognition of bleb scarring and completion of needle revision was 2.2±0.8 days. The time interval between surgery and needle revision was inversely correlated with the time until needle revision (r = -0.694, P<0.001). The mean IOPs before and after needle revision were 24.2±2.7mmHg and 19.6±3.8mmHg, respectively (t = 5.916，P<0.001). At the 12-month follow-up visit, 18 eyes (58.1%) achieved complete success in IOP control, and 6 eyes (19.4%) had conditional success. The overall success rate for needling was thus 77.4%. Subconjunctival hemorrhage was observed in 4 eyes during the needle revision procedure. Punctate staining was found in the corneal epithelium of 2 eyes. Shallow anterior chamber (Grade I or II) was identified in 5 eyes.
Conclusion:
Slit-lamp needle revision combined with subconjunctival injection of interferon α-2b may be efficacious in the treatment of early scarring of filtering blebs, is easy and safe to perform, and may be considered for more widespread application.
