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Performance of routine Helicobacter pylori tests in patients with atrophic gastritis
Agnese Sudraba1, Ilva Daugule, Dace Rudzite
1University of Latvia, Faculty of Medicine, Riga, Latvia. dr.sudraba@latnet.lv
Background:
Decreased density of H. pylori in atrophic gastritis may lead to low sensitivity of the routine tests.
Aims:
To evaluate the accuracy of routinely used H. pylori tests in atrophic gastritis.
Methods:
We compared 5 H. pylori diagnostic tests in 119 dyspeptic patients (28 males/91 females) with a mean age of 67 years (range 55-84). Patients with gastric cancer, peptic ulcer, previous gastric surgery, or those who have received eradication therapy were excluded. The following tests were performed: histology, rapid urease test (RUT), culture, 13C- urea breath tests (UBT), and H.pylori IgG/IgA antibody test (serology).
Results:
Atrophic gastritis was diagnosed in 26.1% of the patients; H. pylori was present in 87.1%. In the group with atrophy, the sensitivity, specificity, positive predictive value, negative predictive value and overall accuracy were as follows: histology (100% for all parameters); UBT (96; 100; 100; 80; 97%); serology (96; 50; 93; 67; 90%); culture (96; 100; 100; 80; 97%); and RUT (78; 100; 100; 40; 81%), respectively.
Conclusions:
Histology, UBT and culture were the three best tests for diagnosing H. pylori infection. We cannot recommend using serology as a single test in a case of atrophy, but it would be reasonable to combine serology with one of the above tests.
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