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[Type V hyperlipemia. 54 cases (author's transl)].

M Schlesinger, B Jacotot, V Beaumont

    La Nouvelle Presse Medicale
    |March 10, 1979
    PubMed
    Summary
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    Type V hyperlipemia, a rare condition, often co-occurs with metabolic issues like diabetes and obesity. Management involves diet and sometimes medication, leading to improved lipid levels and reduced vascular risks.

    Area of Science:

    • Lipidology
    • Metabolic Syndrome
    • Cardiovascular Risk

    Context:

    • Type V hyperlipemia is a rare but significant lipid disorder characterized by elevated chylomicrons and pre-beta-lipoproteins.
    • This condition frequently presents alongside other metabolic derangements, including diabetes, hyperuricemia, gout, and obesity.
    • Chronic alcoholism is a notable comorbidity in a substantial portion of affected individuals.

    Purpose:

    • To describe the clinical characteristics, comorbidities, and treatment outcomes of a large cohort of patients with Type V hyperlipemia.
    • To investigate the association between Type V hyperlipemia and ischemic arterial complications.
    • To evaluate the efficacy of dietary modifications and pharmacological interventions in managing Type V hyperlipemia.

    Summary:

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  • This study details 54 cases of Type V hyperlipemia, the largest series reported, highlighting its association with metabolic syndromes like diabetes and obesity.
  • Chronic alcoholism was present in half the subjects, with hyperlipemia regressing upon alcohol cessation.
  • Ischemic arterial complications, particularly coronary events, occurred in one-third of patients, with elevated vascular risk in hypertensive individuals.

    • Impact:

    • Findings underscore the complex metabolic profile of Type V hyperlipemia and its significant cardiovascular implications.
    • Dietary interventions, including alcohol elimination and calorie/carbohydrate restriction, are effective in normalizing lipid profiles.
    • Pharmacological treatments like clofibrate can be beneficial for refractory cases, aiding in lipid anomaly regression.