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Updated: May 26, 2026

An Optimized LIVE/DEAD Assay Coupled with Flow Cytometry for Quantifying Post-Stress Survival in Yeast Cells
Published on: August 29, 2025
Systems biology of yeast cell death
Ana Joyce Munoz1, Kwanjeera Wanichthanarak, Eugenio Meza
1Department of Chemical and Biological Engineering, Chalmers University of Technology, Göteborg, Sweden.
Abstract:
Programmed cell death (PCD) (including apoptosis) is an essential process, and many human diseases of high prevalence such as neurodegenerative diseases and cancer are associated with deregulations in the cell death pathways. Yeast Saccharomyces cerevisiae, a unicellular eukaryotic organism, shares with multicellular organisms (including humans) key components and regulators of the PCD machinery. In this article, we review the current state of knowledge about cell death networks, including the modeling approaches and experimental strategies commonly used to study yeast cell death. We argue that the systems biology approach will bring valuable contributions to our understanding of regulations and mechanisms of the complex cell death pathways.
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