Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A simple experimental technique for interstitial iridium-192 high dose-rate afterloading.

F Milewsky1, T Fassbender, F Würschmidt

  • 1Institute of Biophysics and Radiobiology, University of Hamburg, FRG.

Strahlentherapie Und Onkologie : Organ Der Deutschen Rontgengesellschaft ... [Et Al]
|September 1, 1990
PubMed
Summary

A new method for interstitial iridium-192 high dose-rate brachytherapy in rats was developed. While effective for tumor treatment, it negatively impacted wound healing in the experimental model.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Treatment and outcomes of patients in the Brain Metastases in Breast Cancer Network Registry.

European journal of cancer (Oxford, England : 1990)·2018
Same author

Clinical, molecular- and cytogenetic analysis of a case of severe radio-sensitivity.

Current genomics·2013
Same author

Time benefit in the assessment of recurrences following fractionated radiotherapy in an experimental tumour system using positron-emission tomography with 18F-fluorodeoxyglucose.

International journal of radiation biology·2004
Same author

Intraindividual comparison of two extracorporeal LDL apheresis methods: lipidfiltration and HELP.

The International journal of artificial organs·2003
Same author

[Radiotherapy for endometrial cancer].

Zentralblatt fur Gynakologie·2002
Same author

Impact of the position of a gap on the response of the R1H-tumor of the rat on fractionated split-course radiotherapy.

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]·2002

Area of Science:

  • Oncology
  • Radiation Oncology
  • Surgical Oncology

Background:

  • Interstitial brachytherapy is a crucial technique in cancer treatment.
  • High dose-rate (HDR) afterloading offers precise radiation delivery.
  • Developing effective animal models is vital for pre-clinical research.

Purpose of the Study:

  • To describe a novel experimental technique for interstitial iridium-192 HDR afterloading brachytherapy.
  • To evaluate the feasibility and impact of this technique on a rat tumor model.
  • To assess the combined effects of brachytherapy and teletherapy on tumor response and wound healing.

Main Methods:

  • Development of a simple experimental technique for interstitial iridium-192 HDR afterloading.
  • Application of the technique to a rat rhabdomyosarcoma R1H tumor model.

Related Experiment Videos

  • Combined brachytherapy and teletherapy treatment delivering 60 Gy in 2 Gy fractions.

    • Main Results:

    • The surgical procedure did not influence the tumor's response to treatment.
    • Animals undergoing afterloading brachytherapy experienced significantly disturbed wound healing.
    • The technique demonstrated potential for experimental brachytherapy in a rat model.

    Conclusions:

    • Interstitial iridium-192 HDR afterloading is a viable experimental technique for rat tumor models.
    • While effective for tumor control, careful consideration of its impact on wound healing is necessary.
    • This model allows for further investigation into the limitations and possibilities of brachytherapy.