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Dialysis

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Related Experiment Video

Updated: May 26, 2026

A Modified EPA Method 1623 that Uses Tangential Flow Hollow-fiber Ultrafiltration and Heat Dissociation Steps to Detect Waterborne Cryptosporidium and Giardia spp.

A Modified EPA Method 1623 that Uses Tangential Flow Hollow-fiber Ultrafiltration and Heat Dissociation Steps to Detect Waterborne Cryptosporidium and Giardia spp.

Published on: July 9, 2012

Producing on-line ultrapure dialysis fluid.

Beat von Albertini¹

¹Clinique Cecil and Service de Néphrologie et Hypertension, Centre Hospitalier et Universitaire Vaudois, Lausanne, Switzerland.

Contributions to Nephrology

|December 23, 2011

Summary

On-line generation of ultrapure dialysis fluid is essential for safe hemodialysis and hemodiafiltration. This technology ensures sterile fluid replacement during renal replacement therapies, protecting patients from harm.

Area of Science:

Nephrology
Biomedical Engineering
Fluid Dynamics

Background:

Modern renal replacement therapies like on-line hemodiafiltration and high-flux hemodialysis require ultrapure dialysis fluid.
Extracorporeal treatments involve significant plasma water removal and replacement, necessitating safe fluid substitution.

Observation:

Historically, sterile and pyrogen-free fluid generation originated from hemofiltration, a convective therapy.
On-line fluid generation relies on membrane ultrafiltration of fresh dialysis fluid.

Findings:

The development of on-line ultrapure dialysis fluid generation has been a decades-long challenge.
This advancement is crucial for the safe execution of advanced dialysis techniques.

Implications:

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Ensures patient safety in renal replacement therapies by providing sterile, pyrogen-free dialysis fluid.
Facilitates the widespread adoption and efficacy of on-line hemodiafiltration and high-flux hemodialysis.
Highlights the collaborative role of clinical researchers and the dialysis industry in therapeutic innovation.