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[Irritable bowel syndrome: frequency and phylogenetic relationship of Blastocystis sp. from Mexican patients]

M E Ramírez-Miranda1, D E Jiménez-González, M E Rodríguez-Campa

  • 1Hospital General Dr. Manuel Gea González, México, D. F.

Revista De Gastroenterologia De Mexico
|December 23, 2011
PubMed
Abstract

Insights

Blastocystis sp. was found in 25% of Irritable Bowel Syndrome (IBS) patients in Mexico. Phylogenetic analysis suggests clonal lineages of this parasite exist globally, linking Mexican strains to those in Japan and Denmark.

Area of Science:

  • Medical Parasitology
  • Molecular Epidemiology
  • Gastroenterology

Context:

  • Irritable Bowel Syndrome (IBS) is increasingly associated with Blastocystis, though its pathogenic role remains debated.
  • Limited research exists on Blastocystis prevalence and phylogeny in Mexico.

Purpose:

  • To determine the frequency of Blastocystis sp. in Mexican IBS patients using molecular methods.
  • To analyze the phylogenetic relationships of identified Blastocystis strains with international isolates.

Summary:

  • This study investigated 62 IBS patients (Rome III criteria) in Mexico, employing colonoscopies, parasitological exams, and PCR for Blastocystis sp.
  • Blastocystis sp. was detected in 25% of IBS patients, all with normal colonoscopies.
  • Phylogenetic analysis revealed Mexican Blastocystis sequences clustering with those from Japan and Denmark, supporting global clonal lineages.

Impact:

  • Provides crucial data on Blastocystis prevalence in Mexican IBS patients.
  • Contributes to understanding the global genetic diversity and clonal spread of Blastocystis.
  • Informs potential diagnostic and therapeutic strategies for IBS patients with Blastocystis infections.

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