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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...

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Updated: May 26, 2026

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
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Ergogenic dietary aids for the elderly.

E Paul Cherniack1

  • 1Geriatrics Institute, Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Miami Miller School of Medicine, and Bruce W. Carter Veterans Affairs Medical Center, Miami, Florida, USA. evan.cherniack@va.gov

Nutrition (Burbank, Los Angeles County, Calif.)
|December 23, 2011
PubMed
Summary
This summary is machine-generated.

Ergogenic dietary aids may support exercise in older adults, with some, like creatine and caffeine, showing potential for improved strength and endurance. However, more research is needed to confirm their safety and effectiveness in the elderly.

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Area of Science:

  • Gerontology
  • Sports Medicine
  • Nutritional Science

Background:

  • Aging leads to decreased physical function in the elderly.
  • Ergogenic aids are supplements used to enhance exercise performance.
  • Limited research exists on ergogenic aids specifically in older populations.

Purpose of the Study:

  • To review the published medical evidence on ergogenic dietary aids for enhancing exercise in the elderly.
  • To assess the efficacy and safety of specific supplements in older adults.

Main Methods:

  • Review of existing medical literature on ergogenic aids in the elderly.
  • Analysis of studies involving creatine, caffeine, β-hydroxy-β-methylbutyrate, ubiquinone, and carnitine.

Main Results:

  • Creatine showed mixed results, improving short-term intense activity capacity.
  • Caffeine may increase endurance but not other exercise parameters.
  • β-hydroxy-β-methylbutyrate showed limited benefits for strength-related activities.
  • Carnitine suggested decreased fatigue and increased endurance.
  • Ubiquinone showed no benefit.
  • Combinations of aids yielded minor improvements in physical function.

Conclusions:

  • Ergogenic aids show potential as adjunctive therapies for exercise in the elderly.
  • Evidence for most supplements is limited due to small sample sizes and short study durations.
  • Further long-term research is necessary to establish the safety and efficacy of these aids in older adults.