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Updated: May 26, 2026

Cerebral Blood Oxygenation Measurement Based on Oxygen-dependent Quenching of Phosphorescence
Published on: May 4, 2011
Oxyneurography: a new technique for the measurement of nerve oxygenation
Joe F Jabre1, Giovanna M Squintani, Kenneth K H Chui
1Department of Neurology, Boston University School of Medicine, 65 Arlington Road, Woburn, Massachusetts 01801, USA. joe.jabre@tufts.edu
Introduction:
Near-infrared spectroscopy (NIRS) is a non-invasive technique used to measure tissue oxygenation. In this study we describe oxyneurography (ONG), a novel application of the NIRS technique in non-invasive surface measurement of oxygenation in ulnar nerve.
Methods:
NIRS sensors were applied directly over the ulnar epicondylar groove to measure the ulnar nerve ONG index, a ratio of oxygenated over total hemoglobin content. Ulnar motor conduction studies were obtained in all subjects.
Results:
The ONG index and ulnar motor conduction had a positive linear association. Ulnar motor conduction could be linearly predicted by the ONG index. The ONG index showed a sensitivity of 1.0 and a specificity of 0.852 for the presence of an ulnar neuropathy symptom. During limb ischemia, the ONG index gradually decreased.
Conclusions:
Oxyneurography can lead to the early detection of a compromise in a nerve's oxygenation status leading to neuropathy.
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