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Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
NMR Spectrometers: Radiofrequency Pulses and Pulse Sequences01:17

NMR Spectrometers: Radiofrequency Pulses and Pulse Sequences

A pulse is a short burst of radio waves distributed over a range of frequencies that simultaneously excites all the nuclei in the sample. Upon passing a radio frequency pulse along the x-axis, the nuclei absorb energy corresponding to their Larmor frequencies and achieve resonance. This shifts the net magnetization vector from the z-axis toward the transverse plane. This angle of rotation of the magnetization vector, or the flip angle, is proportional to the duration and intensity of the pulse.
Atomic Nuclei: Magnetic Resonance01:05

Atomic Nuclei: Magnetic Resonance

The number of nuclear spins aligned in the lower energy state is slightly greater than those in the higher energy state. In the presence of an external magnetic field, as the spins precess at the Larmor frequency, the excess population results in a net magnetization oriented along the z axis. When a pulse or a short burst of radio waves at the Larmor frequency is applied along the x axis, the coupling of frequencies causes resonance and flips the nuclear spins of the excess population from the...
Insensitive Nuclei Enhanced by Polarization Transfer (INEPT)01:15

Insensitive Nuclei Enhanced by Polarization Transfer (INEPT)

Insensitive Nuclei Enhanced by Polarization Transfer (INEPT) is an advanced Nuclear Magnetic Resonance (NMR) technique specifically designed to detect and enhance the signals of low-abundance nuclei, such as carbon-13 and nitrogen-15, in small molecules. The fundamental principle behind INEPT is the transfer of polarization from a more abundant and highly polarizable nucleus, typically hydrogen-1, to the low-abundance nucleus of interest. This process effectively boosts the NMR signal of the...
Double Resonance Techniques: Overview01:12

Double Resonance Techniques: Overview

Double resonance techniques in Nuclear Magnetic Resonance (NMR) spectroscopy involve the simultaneous application of two different frequencies or radiofrequency pulses to manipulate and observe two distinct nuclear spins. One important application of double resonance is spin decoupling, which selectively suppresses coupling with one type of nucleus while observing the NMR signal from another nucleus, simplifying the spectrum and enhancing resolution.
Spin decoupling is usually achieved by...
NMR Spectrometers: Resolution and Error Correction01:14

NMR Spectrometers: Resolution and Error Correction

When magnetic nuclei in a sample achieve resonance and undergo relaxation, the signal detected in NMR is an approximately exponential free induction decay. Fourier transform of an exponential decay yields a Lorentzian peak in the frequency domain. Lorentzian peaks in an NMR spectrum are defined by their amplitude, full width at half maximum, and position, where the peak width is governed by the spin-spin relaxation time alone. In real experiments, however, the applied magnetic field is rendered...

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Frequency Mixing Magnetic Detection Scanner for Imaging Magnetic Particles in Planar Samples
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Frequency Mixing Magnetic Detection Scanner for Imaging Magnetic Particles in Planar Samples

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Null space imaging: nonlinear magnetic encoding fields designed complementary to receiver coil sensitivities for

Leo K Tam1, Jason P Stockmann, Gigi Galiana

  • 1Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06520-8043, USA. lk.tam@yale.edu

Magnetic Resonance in Medicine
|December 23, 2011
PubMed
Summary

Null space imaging offers a novel parallel imaging method for faster MRI scans. This technique enhances spatial encoding efficiency, enabling higher acceleration factors with fewer receiver coils.

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Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Image Acquisition
  • Signal Processing

Background:

  • Parallel imaging techniques accelerate MRI acquisition by leveraging information from multiple receiver coils.
  • Conventional parallel imaging methods like SENSitivity Encoding (SENSE) have limitations in spatial encoding efficiency, especially with limited coil elements.

Purpose of the Study:

  • To develop an alternative gradient encoding strategy for parallel MRI to improve image acquisition efficiency.
  • To introduce 'null space imaging' as a method that complements coil-based spatial encoding.

Main Methods:

  • Developed nonlinear magnetic field gradients to encode spatial information in regions ambiguous to receiver coils.
  • Utilized singular value decomposition to identify the null space of coil sensitivities.
  • Calculated encoding fields from null space vectors, replacing conventional linear gradients and phase encoding.
  • Employed multiple encoding fields as projections to capture null space information.

Main Results:

  • Null space imaging demonstrated effectiveness in providing complementary spatial encoding.
  • The method allows for high acceleration factors with a limited number of receiver coil elements.
  • Evaluated performance against conventional Cartesian SENSE using mean squared error and noise robustness.

Conclusions:

  • Null space imaging presents a time-efficient approach to spatial encoding in parallel MRI.
  • This method enhances acceleration capabilities in MRI by optimizing gradient encoding strategies.
  • Further development of nonlinear encoding schemes holds promise for future MRI advancements.