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Related Experiment Video

Updated: May 26, 2026

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice

Published on: March 11, 2020

Axonal fiber terminations concentrate on gyri.

Jingxin Nie¹, Lei Guo, Kaiming Li

¹Department of Automatic Control, School of Automation, Northwestern Polytechnical University, Xi'an 710072, China.

Cerebral Cortex (New York, N.Y. : 1991)

|December 23, 2011

Summary

Axonal fibers are denser in the gyri than in the sulci of mammalian brains. This finding suggests that axonal pushing may be a key mechanism driving the development of the cerebral cortex and its characteristic folding patterns.

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Electrophysiological Investigations of Retinogeniculate and Corticogeniculate Synapse Function

Electrophysiological Investigations of Retinogeniculate and Corticogeniculate Synapse Function

Published on: August 7, 2019

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Last Updated: May 26, 2026

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice

Published on: March 11, 2020

Electrophysiological Investigations of Retinogeniculate and Corticogeniculate Synapse Function

Electrophysiological Investigations of Retinogeniculate and Corticogeniculate Synapse Function

Published on: August 7, 2019

Area of Science:

Neuroscience
Comparative Anatomy
Developmental Biology

Background:

The mammalian brain exhibits complex cortical folding and intricate neuronal wiring.
The relationship between these features and the principles governing cerebral cortex development are not fully understood.

Purpose of the Study:

To investigate the macroscale relationship between cortical folding and neuronal wiring across mammalian brains.
To identify underlying principles shaping cerebral cortex architecture.

Main Methods:

Diffusion tensor imaging (DTI)
High-angular resolution diffusion imaging (HARDI)
Analysis of axonal fiber density in gyri and sulci across species.

Main Results:

Axonal fibers connected to gyri are significantly denser than those connected to sulci.
A dominant fraction of axonal fibers connect to gyri in human, chimpanzee, and macaque brains.
This finding was replicated across a range of mammalian brains.

Conclusions:

The study reveals a significant difference in axonal fiber density between gyri and sulci.
Axonal pushing is proposed as a potential mechanism driving cortical folding.
Findings may illuminate fundamental mechanisms of cerebral cortex development and organization.