Surmounting chemoresistance by targeting the Y-box binding protein-1
Ikuyo Inoue1, Ken Matsumoto, Yingnan Yu
1Department of Anatomy, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore.
Abstract:
The Y-box binding protein 1 (YB-1), characterized by the presence of the cold shock domain, has been reported to induce chemoresistance in cancer therapy. Chemotherapy is one of the main therapeutic strategies in the treatment of cancer, in addition to surgery, radiation therapy, and hormonal therapy. However, chemoresistance remains a key obstacle to successful cancer management. In this review, we will focus on the role of YB-1, an important regulator of gene transcription, in cancer therapy and chemoresistance.
More Related Videos
Related Concept Videos
Treatment Resistant Cancers
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Treatment Resistent Cancers
Abnormal Proliferation


