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Published on: September 21, 2021
[Preparation of rat model of systemic inflammatory response syndrome induced by zymosan]
Qi-yu Lu1, Yu-yang Zhou, Jun-bo Wang
1Department of Clinical Medicine, Zhejiang University City College, Hangzhou 310015, Zhejiang, China.
Objective:
To establish a model of systemic inflammatory response syndrome (SIRS) in rats.
Methods:
SD rats were intraperitoneally injected with different concentrations of zymosan suspension. The general status, temperature, white cell count, tumor necrosis factor-α(TNF-α), interleukin-6(IL-6), interleukin-10 (IL-10) and the pathological changes of main organs were examined.
Results:
The conditions of rats receiving zymosan doses of 750 mg/kg and 1000 mg/kg were consistent with the criteria of SIRS model; however, the mortality of 1000 mg/kg group was higher than that of 750 mg/kg group.
Conclusion:
The rat model of systemic inflammatory response syndrome has been successfully induced.
