Related Experiment Video
Updated: May 26, 2026
05:45
Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
Published on: July 31, 2017
Challenges in immunotherapy presented by the glioblastoma multiforme microenvironment
Christopher Jackson1, Jacob Ruzevick, Jillian Phallen
1Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Clinical & Developmental Immunology
|December 23, 2011
Summary
Glioblastoma immunotherapy faces challenges from the tumor microenvironment. Understanding these immunosuppressive mechanisms is key to developing effective brain tumor treatments.
Area of Science:
- Neuro-oncology
- Cancer Immunology
Background:
- Glioblastoma multiforme (GBM) is an aggressive brain tumor with poor prognosis.
- Current treatments offer limited survival benefits, necessitating novel therapeutic strategies.
Purpose of the Study:
- To review current immunotherapy approaches for GBM.
- To highlight the challenges posed by the GBM tumor microenvironment.
Main Methods:
- Literature review of immunotherapy strategies for glioblastoma.
- Analysis of the immunosuppressive mechanisms within the GBM tumor microenvironment.
Main Results:
- The tumor microenvironment creates a complex immunosuppressive milieu.
- Multiple signaling pathways, cytokines, and cell types contribute to immune evasion.
Conclusions:
- The intricate tumor microenvironment presents significant hurdles for GBM immunotherapy.
- Further research into overcoming tumor-mediated immunosuppression is crucial for therapeutic advancement.
Related Concept Videos
02:17The Tumor Microenvironment
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
02:17The Tumor Microenvironment
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
01:27Tumor Immunotherapy
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.