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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...

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Related Experiment Video

Updated: May 26, 2026

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
12:13

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

Epigenetics in prostate cancer.

Costantine Albany1, Ajjai S Alva, Ana M Aparicio

  • 1Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana 46202, USA.

Prostate Cancer
|December 23, 2011
PubMed
Summary
This summary is machine-generated.

Epigenetic changes like DNA methylation play a key role in prostate cancer (PC) progression. Targeting these reversible changes offers a promising therapeutic strategy for PC treatment.

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Area of Science:

  • Oncology
  • Epigenetics

Background:

  • Prostate cancer (PC) is a leading cause of cancer death in men.
  • Epigenetics, the study of gene expression changes without altering DNA sequence, involves DNA methylation and histone modification.
  • These epigenetic mechanisms are critical in prostate cancer development and metastasis.

Purpose of the Study:

  • To explore the role of epigenetic mechanisms in prostate cancer.
  • To highlight the potential of targeting epigenetic aberrations for PC treatment.

Main Methods:

  • Review of epigenetic mechanisms in prostate cancer.
  • Analysis of DNA methylation and histone modification roles.

Main Results:

  • Widespread DNA hypermethylation in prostate cancer suggests potential for epigenetic restoration.
  • Histone modification alters tumor gene function and transcription.

Conclusions:

  • Epigenetic aberrations are reversible and can be targeted for therapy.
  • Modulators that demethylate DNA and inhibit histone deacetylases are promising for prostate cancer treatment.