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A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...
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Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...
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Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
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Intracranial Aspergillus granuloma.

C Sundaram1, J M K Murthy

  • 1Department of Pathology, Nizam's Institute of Medical Sciences, Panjagutta, Hyderabad 500 081, India.

Pathology Research International
|December 23, 2011
PubMed
Summary

Intracranial fungal granulomas caused by Aspergillus are rare, often affecting immunocompetent individuals. Sinocranial spread and fibrotic lesions with giant cells are characteristic, influencing treatment.

Area of Science:

  • Neurology
  • Mycology
  • Pathology

Background:

  • Intracranial fungal granulomas are uncommon neurological infections.
  • Aspergillus species are the most frequent fungal pathogens identified in these granulomas.
  • Geographic distribution of reported cases often includes temperate climates.

Purpose of the Study:

  • To review the characteristics of intracranial Aspergillus granulomas.
  • To highlight the epidemiological and etiological factors.
  • To discuss the pathological features and their therapeutic implications.

Main Methods:

  • Review of histologically verified cases of intracranial fungal granulomas.
  • Analysis of epidemiological data, including patient immunity status and environmental factors.

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  • Histopathological examination focusing on fibrosis and giant cell presence.

    • Main Results:

    • Aspergillus spp. are the most common cause of intracranial fungal granulomas.
    • Most affected individuals are immunocompetent, unlike disseminated aspergillosis.
    • Sinocranial spread is the primary route of infection, leading to extracerebral and skull base lesions.
    • Extensive fibrosis and multinucleated giant cells are key histological findings.

    Conclusions:

    • Intracranial Aspergillus granulomas predominantly affect immunocompetent hosts.
    • Environmental factors and sinocranial spread are critical in pathogenesis.
    • Characteristic histopathological features, such as fibrosis and giant cells, are important for diagnosis and treatment planning.