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Protein Complexes with Interchangeable Parts

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Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...

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Directed Evolution Method in Saccharomyces cerevisiae: Mutant Library Creation and Screening

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Multivalent glycocluster design through directed evolution

Iain S MacPherson¹, J Sebastian Temme, Sevan Habeshian

¹Department of Chemistry, Brandeis University, 415 South St., Waltham, MA 02454, USA.

Angewandte Chemie (International Ed. in English)

|December 23, 2011

Summary

No abstract available in PubMed .

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